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3800 Finnerty Rd, Victoria, BC
V8P 5C2
Our Services
We have worked extensively with multiple industrial/biotech partners and >50 academic laboratories to carry out HDX-MS analysis, and are excited to expand to a larger customer base. We offer competitive rates, and first class expertise in the study of challenging H/DX projects.
Our laboratory has made significant progress in the use of HDX-MS to study membrane localized signalling complexes that have been challenging to study by other structural approaches. We provide epitope mapping of antibody binding sites, and mapping of protein-protein interactions. We also provide screening of oncogenic specific drug binding interfaces.
Epitope Mapping of Antibodies
​We can screen multiple nanobodies/antibodies to determine their binding interfaces and allosteric changes induced upon binding
Identify small molecule and substrate binding sites
HDX is powerful to screen small molecule binding pockets and lipid binding sites, and can reveal unexpected allosteric conformational changes
Validation of protein dynamics
We can validate Alphafold structural predictions using HDX, with this useful in the analysis of disordered regions
Learn more
Please visit our webpage for more details: https://jburkelab.wixsite.com/hdexperts